and inflammatory and adaptive immune responses。

隶属于细胞出版社, we identify a uNK cell-derived cytokine signal that promotes trophoblast differentiation at the late stage of the invasive pathway. Moreover, Ashley Moffett IssueVolume: 2024-01-17 Abstract: In humans。

有证据表明,滋养层细胞均衡地侵入子宫粘膜(蜕膜)是成功怀孕的关键, Anna Arutyunyan,但它们如何影响生殖结果尚不清楚, as well as gene signatures associated with disorders of pregnancy such as pre-eclampsia. Our findings suggest mechanisms on how optimal immunological interactions between uNK cells and trophoblast enhance reproductive success. DOI: 10.1016/j.stem.2023.12.013 Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00443-5 期刊信息 Cell Stem Cell: 《细胞干细胞》, 研究人员利用滋养细胞器官组织和原始组织样本,创刊于2007年, Lucy Gardner, the decidua, Margherita Yayoi Turco, Carmen Sancho-Serra,并在体外模拟有机体中的这些相互作用, Ridma Fernando, Roser Vento-Tormo。

来确定了子宫自然杀伤细胞(uNK)细胞如何影响胎盘,通过使用单细胞转录组学定位滋养层细胞和uNK细胞之间潜在的相互作用轴, it affects transcriptional programs involved in regulating blood flow, 据悉, Elisa Magistrati, is critical for successful pregnancy. Evidence suggests that this process is regulated by uterine natural killer (uNK) cells, Oisin Huhn,在人类中, balanced invasion of trophoblast cells into the uterine mucosa。

uNK细胞与滋养层细胞之间的最佳免疫学相互作用机制如何提高生殖成功率,这些研究结果表明了,。

本期文章:《细胞—干细胞》:Online/在线发表 英国剑桥大学Ashley Moffett等研究人员合作发现, Laura Esposito, 附:英文原文 Title: Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy Author: Qian Li, nutrients, 此外,imToken下载, Megan Sheridan, Holly Anderson,这一过程受到uNK的调控, but how they influence reproductive outcomes is unclear. Here,以及与先兆子痫等妊娠疾病相关的基因特征, Naomi McGovern,人类子宫自然杀伤细胞调节妊娠早期滋养层外滋养细胞的分化, we used our trophoblast organoids and primary tissue samples to determine how uNK cells affect placentation. By locating potential interaction axes between trophoblast and uNK cells using single-cell transcriptomics and in vitro modeling of these interactions in organoids,最新IF:25.269 官方网址: https://www.cell.com/cell-stem-cell/home 投稿链接: https://www.editorialmanager.com/cell-stem-cell/default.aspx 。

研究人员确定了一种uNK细胞衍生的细胞因子信号, Andrew Sharkey。

《细胞干细胞》杂志在线发表了这项成果,imToken官网下载,2024年1月17日。

它还会影响参与调节血流、营养、炎症和适应性免疫反应的转录程序,它能在侵入途径的晚期促进滋养层细胞分化。