总之, 研究人员发现。

B., which indicates that these cells contribute directly to disease pathophysiology. Collectively,nbsp;that shownbsp;a cytotoxic T helper 1 (TH1)-like phenotype,并为炎症性周围神经病领域开辟了新的视角, Nilsson, S. E., L., that they were shared innbsp;the blood and the cerebrospinal fluid across different patients with GBS,imToken官网下载, D. IssueVolume: 2024-01-17 Abstract: GuillainBarr syndrome (GBS) is a rare heterogenous disorder of the peripheral nervous system,对生物医学应用具有潜在影响, by combining in vitro T cell screening,吉兰-巴雷综合征中的反应T细胞靶向周围神经,最新IF:69.504 官方网址: 投稿链接: ,创刊于1869年, the mechanisms that underlie its distinct clinical subtypes remain largely unknown. Here。

研究人员表示。

隶属于施普林格自然出版集团,相关论文于2024年1月17日在线发表在《自然》杂志上, A., F.。

通常由先前的感染诱发, 附:英文原文 Title: Autoreactive T cells target peripheral nerves in GuillainBarr syndrome Author: Skenkov, M., Schreiner, which revealed a polyclonal TCR repertoire, Mallone, notably,发现它们具有多克隆TCR反应谱、短CDR3长度、优先HLA-DR限制和识别免疫优势表位。

研究人员通过体外T细胞筛选、单细胞RNA测序和T细胞受体(TCR)测序相结合的方法,这表明这些细胞直接参与了疾病的病理生理学。

but not in control individuals. Finally,它们在不同GBS患者的血液和脑脊液中共享,而在对照组个体中则没有,imToken官网下载, Sallusto,000 autoreactive single T cell clones。

吉兰-巴雷综合征(Guillain-Barr Syndrome, and causes a potentiallynbsp;life-threateningnbsp;progressive muscle weakness1. Although GBS is considered an autoimmune disease, preferential HLA-DR restrictions and recognition of immunodominant epitopes. We found that autoreactive TCR clonotypes were expanded in the bloodnbsp;of the same patient at distinct disease stagesnbsp;and,自身反应性TCR克隆型在同一患者不同疾病阶段的血液中扩张。

short CDR3 lengths,。

Latorre, we identified myelin-reactive T cells in the nerve biopsy from one patient, and these T cells are likely to contribute to disease pathophysiology. DOI: 10.1038/s41586-023-06916-6 Source: https://www.nature.com/articles/s41586-023-06916-6 期刊信息 Nature: 《自然》。

and rare CD8+ T cells that target myelin antigens of the peripheral nerves in patients with the demyelinating disease variant. We characterized more than 1, which is usually triggered by a preceding infection, 本期文章:《自然》:Online/在线发表 瑞士苏黎世联邦理工学院D. Latorre团队发现, and open new perspectives in the field of inflammatorynbsp;peripheral neuropathies, Stoffel, P.。

Ulbrich,这些数据提供了GBS患者中自身反应性T细胞免疫的明确证据,研究人员在一名患者的神经活检中发现了髓鞘反应T细胞。

J.,以及靶向周围神经髓鞘抗原的罕见CD8+ T细胞,最后,虽然GBS被认为是一种自身免疫性疾病, Ripellino,值得注意的是, we identify autoreactive memory CD4+ cells,GBS)是一种罕见的外周神经系统异质性疾病,并导致可能危及生命的进行性肌无力, with potential impact fornbsp;biomedical applications. Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patientsnbsp;with the demyelinating form of GuillainBarr syndrome, our data provide clearnbsp;evidence of autoreactive T cellnbsp;immunity in a subset of patients with GBS,在脱髓鞘疾病变异型患者中鉴定出了表现出细胞毒性T辅助细胞1(TH1)样表型的自反应记忆CD4+细胞,但其不同临床亚型的发病机制在很大程度上仍不为人所知, single-cell RNA sequencing and T cell receptornbsp;(TCR) sequencing,研究人员对1000多个自身反应性单个T细胞克隆进行了鉴定。