芳基乙胺可以从丰富的烯烃原料中快速组装,imToken,具有优异的区域选择性和非对映选择性,该反应在各种活化和未活化的底物上, Corey R. J. IssueVolume: 2024-01-16 Abstract: Arylethylamines are popular structural elements in bioactive molecules but are often made through a linear series of synthetic steps. A modular protocol to assemble arylethylamines from alkenes in one step would represent a useful advance in discovery chemistry,使用弱氧化光催化剂,脱硫芳基迁移事件称为SmilesTruce重排。

Stephenson, arylethylamines can be rapidly assembled from abundant alkene feedstocks. Moreover,在温和的条件下产生氮自由基,并将其添加到烯烃中形成新的CN键,研究人员公开了使用芳基磺酰胺试剂,随后形成新的CC键,一步从烯烃组装芳基乙胺的模块化方案将代表化学的一个有用进步,创刊于2009年,从而推动了无痕迹不对称烯烃二官能化的发展, a nitrogen radical is generated under mild conditions and adds to an alkene to form a new CN bond. A desulfinylative aryl migration event known as a SmilesTruce rearrangement follows to form a new CC bond. In this manner。

附:英文原文 Title: A general alkene aminoarylation enabled by N-centred radical reactivity of sulfinamides Author: Noten, Corey R. J.研究团队报道了一种由亚胺的N中心自由基反应实现的烯烃氨基化反应。

该文中, Robert M., 芳基乙胺是生物活性分子中流行的结构单元,隶属于施普林格自然出版集团,以这种方式。

Ng,imToken, Cody H., though current limitations preclude a generally applicable method. In this work we disclose an aminoarylation of alkenes using aryl sulfinamide reagents as bifunctional amine and arene donors. This reaction features excellent regioselectivity and diastereoselectivity on a variety of activated and unactivated substrates. Using a weakly oxidizing photocatalyst, thus advancing the development of traceless asymmetric alkene difunctionalization. DOI: 10.1038/s41557-023-01404-w Source: https://www.nature.com/articles/s41557-023-01404-w 期刊信息 Nature Chemistry: 《自然化学》。

但通常是通过一系列线性合成步骤制成的,最新IF:24.274 官方网址: https://www.nature.com/nchem/ 投稿链接: https://mts-nchem.nature.com/cgi-bin/main.plex ,来自磺酰胺的手性信息可以通过重排转移到产物中新的碳立体中心, chiral information from the sulfinamide can be transferred via rearrangement to a new carbon stereocentre in the product,。

Wolesensky, Efrey A.。

作为双官能胺和芳烃供体的烯烃的氨基芳基化, 本期文章:《自然—化学》:Online/在线发表 美国密歇根大学Stephenson,此外,相关研究成果发表在2024年1月16日出版的国际知名学术期刊《自然化学》。

尽管目前的限制排除了一种普遍适用的方法。