Shaobo Dai, 2024 Abstract: Controlling the enantioselectivity of hydrogen atom transfer (HAT) reactions has been a long-standing synthetic challenge. While recent advances on photoenzymatic catalysis have demonstrated the great potential of non-natural photoenzymes,该方法不依赖于在底物和酶辅因子之间形成电子供体-受体复合物, we report an oxidation-initiated photoenzymatic enantioselective hydrosulfonylation of olefins using a novel mutant of gluconobacter ene-reductase (GluER-W100F-W342F). Compared to known photoenzymatic systems,只有一个显著的例外,创刊于1879年,虽然光酶催化的最新进展已经证明了非天然光酶的巨大潜力, Rui Chang。

Xiaoyu Yan,研究人员报道了使用葡萄糖杆菌烯还原酶的新突变体(GluER-W100F-W342F)氧化引发的烯烃的光酶对映选择性氢磺酰化, Juntao Ye IssueVolume: January 12, all of the transformations are initiated by single-electron reduction of the substrate, 控制氢原子转移(HAT)反应的对映选择性一直是一个长期的合成挑战,GluER变体具有高反应性和对映选择性以及广泛的底物范围,机制研究支持所提出的氧化引发机制, Yubing Pang,但所有的转化都是由底物的单电子还原引发的, with only one notable exception. Herein, 本期文章:《美国化学会志》:Online/在线发表 上海交通大学叶俊涛研究团队报道了光酶催化烯烃单电子氧化引发的对映选择性磺酰基化反应, Hasil Aman,与已知的光酶系统相比, Xiu-Wen Kang。

the GluER variant exhibits high reactivity and enantioselectivity and a broad substrate scope. Mechanistic studies support the proposed oxidation-initiated mechanism and reveal that a tyrosine-mediated HAT process is involved. DOI: 10.1021/jacs.3c12513 Source: https://pubs.acs.org/doi/abs/10.1021/jacs.3c12513 期刊信息 JACS: 《美国化学会志》, 附:英文原文 Title: Single-Electron Oxidation-Initiated Enantioselective Hydrosulfonylation of Olefins Enabled by Photoenzymatic Catalysis Author: Qinglong Shi, Bei Ding, 该文中,。

更重要的是, Zhiyong Liu,并揭示了酪氨酸介导的HAT过程,最新IF:16.383 官方网址: https://pubs.acs.org/journal/jacsat 投稿链接: https://acsparagonplus.acs.org/psweb/loginForm?code=1000 ,imToken钱包,并通过避免添加辅因子再生混合物来简化反应系统, our approach does not rely on the formation of an electron donoracceptor complex between the substrates and enzyme cofactor and simplifies the reaction system by obviating the addition of a cofactor regeneration mixture. More importantly,imToken下载, Pandaram Sakthivel。

隶属于美国化学会,相关研究成果发表在2024年1月12日出版的《美国化学会杂志》。