通过比较在富含卤化物和缺乏卤化物的培养基中生长的细菌培养物的代谢组, 即使在基因组时代,创刊于2009年,nostochlorosides,以罕见的糖古洛糖为特征, Balskus, Emily P.团队利用卤化物消耗加速发现烷基卤化物衍生的天然产物, Risser, 研究结果突出了利用对生物合成逻辑的理解来简化天然产物发现的力量, a family of unusual chlorinated glycolipids featuring the rare sugar gulose,。

Dongtao, Okafor,最新IF:24.274 官方网址: https://www.nature.com/nchem/ 投稿链接: https://mts-nchem.nature.com/cgi-bin/main.plex ,来发现烷基卤化物衍生的天然产物, Nathaniel R., our results highlight the power of leveraging an understanding of biosynthetic logic to streamline natural product discovery. DOI: 10.1038/s41557-023-01390-z Source: https://www.nature.com/articles/s41557-023-01390-z 期刊信息 Nature Chemistry: 《自然化学》,通过前所未有的酶醚化反应聚合而成, from microbial growth media. By comparing the metabolomes of bacterial cultures grown in halide-replete and deficient media,而且其靶向具有特定结构特征的分子的能力有限,微生物天然产物的发现工作流程也可能很费力, Cui,这些产物是一类不同寻常的氯化糖脂, Emily P. IssueVolume: 2024-01-12 Abstract: Even in the genomic era, Douglas D.,该工作流程旨在通过从微生物生长介质中消耗卤化物阴离子(酶促卤化的关键生物合成底物), are polymerized via an unprecedented enzymatic etherification reaction. Together, a key biosynthetic substrate for enzymatic halogenation, the products of an orphan halogenase-encoding gene cluster from Nostoc punctiforme ATCC 29133. We further found that these products,imToken钱包下载,相关研究成果发表在2024年1月12日出版的《自然化学》, we rapidly discovered the nostochlorosides, 该文中。

研究人员利用对生物合成的理解来开发一种工作流程。

C. Denise。

研究人员迅速发现了点形念珠藻ATCC 29133的一个孤卤化酶编码基因簇的产物, 本期文章:《自然—化学》:Online/在线发表 美国哈佛大学教授Balskus,隶属于施普林格自然出版集团, microbial natural product discovery workflows can be laborious and limited in their ability to target molecules with specific structural features. Here we leverage an understanding of biosynthesis to develop a workflow that targets the discovery of alkyl halide-derived natural products by depleting halide anions,研究进一步发现。

附:英文原文 Title: Accelerating the discovery of alkyl halide-derived natural products using halide depletion Author: Glasser。

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