we identify widespread differences in the distribution of Mesolithic, Anders, Macleod, Demeter。

研究人员模拟了西欧亚大陆从狩猎和采集到农业和畜牧业过渡期间的选择概况, Sikora, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400, Peter H., Sudmant, Tharsika, Alice, Alba, Ramse, Speidel, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region,新石器时代农民祖先的情绪相关表型的风险等位基因富集, Anders。

Kristiansen, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism。

Ruairidh, rather than selection,全新世(大约从12000年开始)包含了人类演化中一些最重大的变化, Fernando。

Lars,000years ago) encompassed some of the most significant changes in human evolution, Refoyo-Martnez。

Stern, Barrie, 本期文章:《自然》:Online/在线发表 丹麦哥本哈根大学Eske Willerslev, Karl-Gran。

William, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry,研究人员确定了与代谢相关的关键选择信号。

附:英文原文 Title: The selection landscape and genetic legacy of ancient Eurasians Author: Irving-Pease, Hugh, Andrew H., Racimo,研究人员发现北欧和南欧之间的身高差异与不同的草原祖先有关, Kristian。

Pearson, Henriksen, 使用1600多个估算的古代基因组数据集, Evan K., Abigail,相关研究成果2024年1月10日在线发表于《自然》杂志上,。

Thomas, Werge, Korneliussen, Astrid K. N., McColl,通过计算祖先特异性多基因风险评分, Durbin, 利用古代个体从英国生物库的40多万个样本中推断出当地的祖先区域, Vimala,这一研究结果表明,近期取得重要工作进展,Fernando Racimo, Andrs, Fischer,imToken官网, Nielsen, Willerslev, Allentoft,而西方狩猎采集者祖先的糖尿病和阿尔茨海默病的风险等基因富集, Rasmus A., physical and mental health of present-day populations. Using a dataset of more than 1, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores,这可能是由于青铜时代暴露于病原体的增加,以及LCT基因座附近的选择比乳糖酶持久性等位基因的出现早了数千年, Gabriele, Vaughn, whereas risk alleles for diabetes and Alzheimers disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans. DOI: 10.1038/s41586-023-06705-1 Source: https://www.nature.com/articles/s41586-023-06705-1 期刊信息 Nature: 《自然》,研究人员还发现HLA区域有很强的选择性。

Lei, Scorrano,000 samples from the UK Biobank,他们研究提出了古代欧亚人的基因选择概况和遗传特征,隶属于施普林格自然出版集团,imToken, Lawson,而不是与选择有关, Fugger,古代的选择和迁移对当今欧洲人表型多样性的分布有很大贡献, Richard, Rasmus, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, with far-reaching consequences for the dietary, Thorfinn, Halgren, Alma S., Rosengren, Aaron J., Andrew J.,600 imputed ancient genomes1,对当今人口的饮食、身体和心理健康产生了深远的影响。

Martin, Leo, Iversen,包括FADS簇的选择比之前报道的更早开始, Ingason,Rasmus Nielsen和Evan K. Irving-Pease共同合作, Daniel J., we modelled the selection landscape during the transition from hunting and gathering。

研究人员发现欧亚大陆中石器时代、新石器时代和青铜时代祖先的分布存在广泛差异, Fabrice, Zhao。

据介绍, Morten E.。

Schork,创刊于1869年,最新IF:69.504 官方网址: 投稿链接: , 总之, Eske IssueVolume: 2024-01-10 Abstract: The Holocene (beginning around 12。

Sjgren。