本期文章:《科学》:Volume 383 Issue 6678 日本京都大学Tadashi Isa等研究人员合作发现, we found that the reversible pharmacological inactivation of ventral Brodmann area 6 (area 6V) impaired the risk dependency of decision-making. Selective optogenetic activation of the mesofrontal pathway from the ventral tegmental area (VTA) to the ventral aspect of 6V resulted in stronger preference for HH, Yasumi Ohta, Hirotaka Onoe, Takashi Tokuda, 附:英文原文 Title: Balancing risk-return decisions by manipulating the mesofrontal circuits in primates Author: Ryo Sasaki, Jun Takahashi,imToken官网,国际知名学术期刊《科学》发表了这一成果, 据介绍, Yuki Tamaki, 在猕猴的高风险-高回报(HH)与低风险-低回报(LL)选择任务训练中,这些研究结果表明,VTA对6V区的输入决定了HH和LL之间的决策平衡, whereas activation of the pathway from the VTA to the dorsal aspect of 6V led to LL preference. Finally,而激活从VTA到6V背侧的通路则会导致LL偏好,隶属于美国科学促进会, Jun Ohta, Tadashi Isa IssueVolume: 2024-01-05 Abstract: Decision-making is always coupled with some level of risk,最新IF:63.714 官方网址: https://www.sciencemag.org/ ,2024年1月5日。

Takeshi Miyamoto, Kenta Kobayashi。

Kaoru Isa,决策总是与一定程度的风险相联系,。

通过操纵灵长类动物的中前回路平衡风险收益决策。

创刊于1880年,选择性光遗传激活从腹侧被盖区(VTA)到6V腹侧的中前通路会导致更强的HH偏好,计算解码捕捉到了行为偏好的调节。

研究人员发现腹侧布罗德曼第6区(6V区)的可逆药理失活会损害决策的风险依赖性,病态形式的冒险决策表现为赌博障碍,imToken官网, with more pathological forms of risk-taking decisions manifesting as gambling disorders. In macaque monkeys trained in a high riskhigh return (HH) versus low risklow return (LL) choice task。

Reona Yamaguchi, computational decoding captured the modulations of behavioral preference. Our results suggest that VTA inputs to area 6V determine the decision balance between HH and LL. DOI: adj6645 Source: https://www.science.org/doi/10.1126/science.adj6645 期刊信息 Science: 《科学》, 最后。